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This approach allows the incorporation of non-standard amino acids, such as D-isomers and N-methylated residues, that enhance proteolytic resistance and membrane permeability [49,50]
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The FDA has additionally reported that some semaglutide products sold by compounders may be salt forms such as semaglutide sodium or semaglutide acetate, which the agency describes as different active ingredients than those used in the approved drugs, with unknown comparability of chemical and pharmacologic properties
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