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Safer Alternatives For routine pain relief while on Zepbound, consider: Acetaminophen: Effective for most types of pain without GI irritation Topical anti-inflammatories: Diclofenac gel (Voltaren) provides localized relief without systemic GI exposure Non-drug approaches: Ice, heat, stretching, and rest for musculoskeletal pain Frequently Asked Questions Will Zepbound delay how fast ibuprofen works
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