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However, metformin has been shown to enhance the translocation of GLUT2 to the apical membrane of enterocytes (Ke et al., 2023)

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Gut peptide hormones such as GLP-1 could potentially also have an impact on appetite regulation by effects on gastric emptying and direct CNS effects, but we needed a robust methodology that could be used to measure acute effect of putative hormones on subjective appetite and spontaneous food intake